Sodium Hydroxide → HCID 86655511, compound

HRID 1746565Notes

Reaction equation

HRID 1746565 reaction equation
[CH3:1][O:2][C:3]1[CH:29]=[CH:28][C:6]([CH2:7][C@@H:8]([C:24]([O:26]C)=[O:25])[NH:9][C:10](=[O:23])[CH:11]=[CH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:22])([F:21])[F:20])=[CH:5][CH:4]=1.[OH-].[Na+]>CO>[CH3:1][O:2][C:3]1[CH:29]=[CH:28][C:6]([CH2:7][C@@H:8]([C:24]([OH:26])=[O:25])[NH:9][C:10](=[O:23])[CH:11]=[CH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:21])([F:20])[F:22])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86655472HCID 86655472, compound

Product 1

HCID 86655511HCID 86655511, compoundYield 83.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The same procedures as in Example 64 were carried out from the compound obtained in Example 43 (4.1 g), 1 mol/L of an aqueous sodium hydroxide solution (15 mL), and methanol (150 mL), to give the captioned compound (3.3 g, 83%) as crystals.

Sources & evidence

ORD record
ord-bc7e3d9fdc5c4f018a8dc10e751c5628
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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