Sodium Hydroxide → HCID 86655515, compound

HRID 1746569Notes

Reaction equation

HRID 1746569 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]=[CH:10][C:11]([NH:13][C@H:14]([C:24]([O:26]C)=[O:25])[CH2:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1)=[O:12].[OH-].[Na+]>CO>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]=[CH:10][C:11]([NH:13][C@H:14]([C:24]([OH:26])=[O:25])[CH2:15][C:16]1[CH:17]=[CH:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=1)=[O:12]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86655475HCID 86655475, compound

Product 1

HCID 86655515HCID 86655515, compoundYield 96.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The same procedures as in Example 64 were carried out from the compound obtained in Example 47 (2.9 g), 1 mol/L of an aqueous sodium hydroxide solution (12 mL), and methanol (120 mL), to give the captioned compound (2.7 g, 96%) as crystals.

Sources & evidence

ORD record
ord-3d06854272074f7797f1ac1e2f2e77b6
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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