Sodium Hydroxide → HCID 67130649, compound

HRID 1746570Notes

Reaction equation

HRID 1746570 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[CH:9]=[CH:10][C:11]([NH:13][C@H:14]([C:24]([O:26]C)=[O:25])[CH2:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1)=[O:12].[OH-].[Na+]>CO>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[CH:9]=[CH:10][C:11]([NH:13][C@H:14]([C:24]([OH:26])=[O:25])[CH2:15][C:16]1[CH:17]=[CH:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=1)=[O:12]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86655476HCID 86655476, compound

Product 1

HCID 67130649HCID 67130649, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The same procedures as in Example 64 were carried out from the compound obtained in Example 48 (2.8 g), 1 mol/L of an aqueous sodium hydroxide solution (11 mL), and methanol (110 mL), to give the captioned compound (2.4 g, 89%) as crystals.

Sources & evidence

ORD record
ord-e954ca0c93ef4c9d8116f7196a5da819
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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