Sodium Hydroxide → HCID 86655516, compound

HRID 1746571Notes

Reaction equation

HRID 1746571 reaction equation
[F:1][C:2]([F:33])([F:32])[C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][C:15]([NH:17][C@H:18]([C:28]([O:30]C)=[O:29])[CH2:19][C:20]2[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=2)=[O:16])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[OH-].[Na+]>CO>[F:1][C:2]([F:32])([F:33])[C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][C:15]([NH:17][C@H:18]([C:28]([OH:30])=[O:29])[CH2:19][C:20]2[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=2)=[O:16])[CH:6]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:8]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86655477Methyl N-{3-[3,5-Bis(trifluoromethyl)phenyl]acryloyl}-O4-Methyl-L-Tyrosinate

Product 1

HCID 86655516HCID 86655516, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The same procedures as in Example 90 were carried out from the compound obtained in Example 49 (3.4 g), 1 mol/L of an aqueous sodium hydroxide solution (11 mL), and methanol (110 mL), to give the captioned compound (2.3 g, 71%) as crystals.

Sources & evidence

ORD record
ord-083c751313e744528c6c61fe1945b703
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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