1,4-Dioxane hydrochloride → HCID 67130711, compound

HRID 1746578Notes

Reaction equation

HRID 1746578 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]=[CH:9][C:10]([NH:12][C@H:13]([C:25]([OH:27])=[O:26])[CH2:14][CH2:15][CH2:16][NH:17]C(OC(C)(C)C)=O)=[O:11].[ClH:28].O1CCOCC1>C(Cl)Cl>[ClH:28].[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]=[CH:9][C:10]([NH:12][C@H:13]([C:25]([OH:27])=[O:26])[CH2:14][CH2:15][CH2:16][NH2:17])=[O:11]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86655519HCID 86655519, compound

Product 1

HCID 67130711HCID 67130711, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 29 were carried out from the compound obtained in Example 111 (5.4 g), 4 mol/L of hydrogen chloride-dioxane (11 mL), and methylene chloride (200 mL), to give the captioned compound (4.1 g, 90%) as crystals.

Sources & evidence

ORD record
ord-7dd0ca7e09ad46808abd7ef40e8d7c4d
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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