1,4-Dioxane hydrochloride → HCID 67312025, compound

HRID 1746598Notes

Reaction equation

HRID 1746598 reaction equation
C(OC([NH:8][C@H:9]([C:22]([O:24][CH3:25])=[O:23])[CH2:10][C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]([CH2:20][CH3:21])[CH:12]=1)=O)(C)(C)C.[ClH:26].O1CCOCC1>C(Cl)Cl>[ClH:26].[CH2:20]([N:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11]([CH2:10][C@@H:9]([C:22]([O:24][CH3:25])=[O:23])[NH2:8])=[CH:12]1)[CH3:21]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 67130488HCID 67130488, compound

Product 1

HCID 67312025HCID 67312025, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To methylene chloride (175 mL) solution of the compound obtained in Example 140 (4.8 g) was added dropwise 4 mol/L of hydrogen chloride-dioxane solution (17.5 mL) at room temperature, and the mixture was allowed to stir for 17 hours. The crystals precipitated were filtered, and washed with diethyl ether, to give the captioned compound (2.9 g, 74%).

Workup

  1. customThe crystals precipitated
  2. filtrationwere filtered
  3. washwashed with diethyl ether

Sources & evidence

ORD record
ord-8f04c5e48e884dddba346d12fb1bc618
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

Loading…