HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 67130781, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-(2-Fluorophenyl)prop-2-enoic acid | HCID 67977 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 67312025 | HCID 67312025 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 67130781 | HCID 67130781 | 70% |
Reaction Steps
Triethylamine (1.5 mL), 2-fluorocinnamic acid (1.8 g) and WSC.HCl (2.1 g) were at 0° C. added to methylene chloride (70 mL) suspension of the compound obtained in Example 143 (2.8 g). The mixture was stirred for 4 hours at room temperature. The reaction mixture was washed with water, and thereafter the organic layer was dried over anhydrous sodium sulfate. The residue obtained by distilling off the solvent under a reduced pressure was purified with silica gel column chromatography (chloroform), to give the captioned compound (2.7 g, 70%) as crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150510B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-0ca2c565cd474f928880272048898dfc |
| Source note | uspto-grants-2015_10 |