Sodium Hydroxide → HCID 86655532, compound

HRID 1746603Notes

Reaction equation

HRID 1746603 reaction equation
[OH-].[Na+].[CH2:3]([N:5]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:7]([CH2:8][C@@H:9]([C:22]([O:24]C)=[O:23])[NH:10][C:11](=[O:21])[CH:12]=[CH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])=[CH:6]1)[CH3:4]>CO>[CH2:3]([N:5]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:7]([CH2:8][C@@H:9]([C:22]([OH:24])=[O:23])[NH:10][C:11](=[O:21])[CH:12]=[CH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])=[CH:6]1)[CH3:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67130781HCID 67130781, compound

Product 1

HCID 86655532HCID 86655532, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

One mol/L of an aqueous sodium hydroxide solution (9.9 mL) was added dropwise to methanol (100 mL) solution of the compound obtained in Example 146 (2.6 g) at room temperature. The mixture was allowed to stir for 23 hours. The reaction mixture was concentrated to a ⅕ volume, added with water, and made acidic with dilute hydrochloric acid. The crystals precipitated were filtered, and washed with water, to give the captioned compound (2.3 g, 93%).

Workup

  1. concentrationThe reaction mixture was concentrated to a ⅕ volume
  2. additionadded with water
  3. customThe crystals precipitated
  4. filtrationwere filtered
  5. washwashed with water

Sources & evidence

ORD record
ord-9f404228cbf5434ca9daa30553b31d29
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

Loading…