Sodium Hydroxide → HCID 86655534, compound

HRID 1746605Notes

Reaction equation

HRID 1746605 reaction equation
[CH2:1]([N:5]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:7]([CH2:8][C@@H:9]([C:22]([O:24]C)=[O:23])[NH:10][C:11](=[O:21])[CH:12]=[CH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])=[CH:6]1)[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>CO>[CH2:1]([N:5]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:7]([CH2:8][C@@H:9]([C:22]([OH:24])=[O:23])[NH:10][C:11](=[O:21])[CH:12]=[CH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])=[CH:6]1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67311725HCID 67311725, compound

Product 1

HCID 86655534HCID 86655534, compoundYield 88.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The same procedures as in Example 149 were carried out from the compound obtained in Example 148 (2.1 g), 1 mol/L of an aqueous sodium hydroxide solution (7.5 mL), and methanol (75 mL), to give the captioned compound (1.8 g, 87%) as crystals.

Sources & evidence

ORD record
ord-fa438e80f00d4359ad1e61dbcec9cb12
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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