Sodium Hydroxide → HCID 67130531, compound

HRID 1746622Notes

Reaction equation

HRID 1746622 reaction equation
[C:1]([NH:7][C@H:8]([C:19]([O:21]C)=[O:20])[CH2:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[NH:12][CH:11]=1)(=[O:6])/[C:2](=[CH:4]/[CH3:5])/[CH3:3].[OH-].[Na+]>CO>[C:1]([NH:7][C@H:8]([C:19]([OH:21])=[O:20])[CH2:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[NH:12][CH:11]=1)(=[O:6])/[C:2](=[CH:4]/[CH3:5])/[CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86655535HCID 86655535, compound

Product 1

HCID 67130531HCID 67130531, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The same procedures as in Example 171 were carried out from the compound obtained in Example 163 (3.5 g), 1 mol/L of an aqueous sodium hydroxide solution (18 mL), and methanol (180 mL), to give the captioned compound (2.3 g, 70%) as an amorphous solid product.

Sources & evidence

ORD record
ord-64b98af0bb6d42349d3ad2c0a1a70a69
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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