Iodine → HCID 178526495, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 5-nitro-1H-indazole (Aldrich, 5.0 g; 30.7 mmol) in DMF (60 ml) was treated with iodine (15.6 g; 61.4 mmol) and potassium hydroxide (6.45 g; 115 mmol) at 65° C. After stirring at 65° C. for 1 hour the mixture was poured into saturated sodium metabisulfate solution (200 ml) and the solid removed by filtration, washed with water and dried to give the title compound as a light brown solid (8.9 g, quant).

Provenance & Evidence