HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-(4-nitrophenylsulfonyl)butanoate → Ethyl 4-(4-aminophenylsulfonyl)butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-(4-nitrophenylsulfonyl)butanoate | HCID 59446990 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 4-(4-aminophenylsulfonyl)butanoate | HCID 59446984 | 98.9% |
Reaction Steps
A solution of ethyl 4-(4-nitrophenylsulfonyl)butanoate (Intermediate 47, 4.5 g; 14.9 mmol) in ethanol (200 ml) was treated with palladium (450 mg, 5% on C). The mixture was stirred under hydrogen for 18 hours, filtered and the solvent removed in vacuo to give the title compound as an off-white solid (4.0 g, quant).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150519B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-1872a812c3734be39c263b3abb4eebf4 |
| Source note | uspto-grants-2015_10 |