4-Aminophenol → 6-(cyclopentylamino)-N-(4-hydroxyphenyl)pyrimidine-4-carboxamide

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Reaction Steps

Following the general method as outlined in Example 1, starting from 6-[(cyclopentyl)amino]pyrimidine-4-carboxylic acid (Intermediate 5) and 4-aminophenol (Aldrich), the title compound was obtained as a yellow solid after trituration in acetonitrile. 1H NMR (300MHz, DMSO-d6) δ [ppm] 10.22 (1H, s), 9.32 (1H, s), 8.52 (1H, s), 7.85 (1H, d, J=7.0 Hz), 7.62 (2H, d, J=9.0 Hz), 7.13 (1H, s), 6.72 (2H, d, J=9.0 Hz), 4.28 (1H, m), 1.94 (2H, m), 1.74-1.40 (6H, m). MS (ESI+): 299.1. HPLC (Condition A): Rt 2.17 min (HPLC purity 96.6%).

Provenance & Evidence