4-Amino-3-chlorophenol → HCID 25182746, compound

HRID 1746694Notes

Reaction equation

HRID 1746694 reaction equation
[CH:1]1([NH:7][C:8]2[N:13]=[CH:12][N:11]=[C:10]([C:14]([OH:16])=O)[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:17][C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][C:19]=1[Cl:25]>ClCCl>[Cl:25][C:19]1[CH:20]=[C:21]([OH:24])[CH:22]=[CH:23][C:18]=1[NH:17][C:14]([C:10]1[CH:9]=[C:8]([NH:7][CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)[N:13]=[CH:12][N:11]=1)=[O:16]

Participants

4

Reactant 2

HCID 871844-Amino-3-chlorophenolHCID 594470756-(Cyclohexylamino)pyrimidine-4-carboxylic acid2×

Product 1

HCID 25182746HCID 25182746, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following the general method as outlined in Example 1, starting from 6-(cyclohexylamino)pyrimidine-4-carboxylic acid (Intermediate 4) and 4-amino-3-chlorophenol (Chontech), the title compound was obtained as a white solid after trituration in dichloromethane.

Sources & evidence

ORD record
ord-da5ffd7cf0d644ce8253b8eab30615ea
Source dataset
uspto-grants-2015_10
Patent number
US09150519B2

Reaction notes

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