4-Amino-2,5-dimethylphenol → HCID 25182748, compound

HRID 1746696Notes

Reaction equation

HRID 1746696 reaction equation
[CH:1]1([NH:7][C:8]2[N:13]=[CH:12][N:11]=[C:10]([C:14]([OH:16])=O)[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:17][C:18]1[C:23]([CH3:24])=[CH:22][C:21]([OH:25])=[C:20]([CH3:26])[CH:19]=1>>[CH:1]1([NH:7][C:8]2[N:13]=[CH:12][N:11]=[C:10]([C:14]([NH:17][C:18]3[CH:19]=[C:20]([CH3:26])[C:21]([OH:25])=[CH:22][C:23]=3[CH3:24])=[O:16])[CH:9]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 765444-Amino-2,5-dimethylphenolHCID 594470756-(Cyclohexylamino)pyrimidine-4-carboxylic acid2×

Product 1

HCID 25182748HCID 25182748, compound

Procedure

Following the general method as outlined in Example 1, starting from 6-(cyclohexylamino)pyrimidine-4-carboxylic acid (Intermediate 4) and 4-amino-2,5-dimethylphenol (Aldrich), the title compound was obtained as a white solid yield after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.

Sources & evidence

ORD record
ord-15c5fe97a38a4bbfbf8652e38d8a703e
Source dataset
uspto-grants-2015_10
Patent number
US09150519B2

Reaction notes

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