4-Aminopyridine → HCID 25182750, compound

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Reaction Steps

Following the general method as outlined in Example 1, starting from 6-(cyclohexylamino)pyrimidine-4-carboxylic acid (Intermediate 4) and 4-aminopyridine (Aldrich), the title compound was obtained as a yellow solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc. 1H NMR (300MHz, DMSO-d6) δ [ppm] 10.82 (1H, s), 8.56 (1H, s), 8.47 (2H, d, J=5.0 Hz), 7.89 (2H, d, J=5.0 Hz), 7.84 (1H, d, J=9.0 Hz), 7.16 (1H, s), 3.88 (1H, m), 1.91-1.57 (5H, m), 1.39-1.16 (5H, m). MS (ESI): 298.0. HPLC (Condition A): Rt 2.12 min (HPLC purity 99.4%).

Provenance & Evidence