HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-hydroxybenzotrifluoride → 6-(cyclohexylamino)-N-(4-hydroxy-2-(trifluoromethyl)phenyl)pyrimidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-hydroxybenzotrifluoride | HCID 14692834 | — |
| Reactant | 6-(Cyclohexylamino)pyrimidine-4-carboxylic acid | HCID 59447075 | — |
| Product | 6-(cyclohexylamino)-N-(4-hydroxy-2-(trifluoromethyl)phenyl)pyrimidine-4-carboxamide | HCID 25182753 | — |
Reaction Steps
Following the general method as outlined in Example 1, starting from 6-(cyclohexylamino)pyrimidine-4-carboxylic acid (Intermediate 4) and 4-amino-3-(trifluoromethyl)phenol (prepared according to the method described by Filler, R.; Novar, H. J. in Org. Chem. 1961, 26, 2707-2710″), the title compound was obtained as a white solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150519B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-fc73bd879cac4ab3b925c700e43418de |
| Source note | uspto-grants-2015_10 |