HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cycloheptylamine → 6-(cycloheptylamino)-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cycloheptylamine | HCID 2899 | — |
| Reactant | 6-chloro-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamide | HCID 59447105 | — |
| Product | 6-(cycloheptylamino)-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamide | HCID 25182761 | — |
Reaction Steps
Following the general method as outlined in Example 20, starting from 6-chloro-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamide (Intermediate 8) and cycloheptylamine (Aldrich), the title compound was obtained as a beige solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150519B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-7f488fe3e27c463f9d7cb4e02dc3cea1 |
| Source note | uspto-grants-2015_10 |