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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1746712Generated: October 31, 2026

N-(4-amino-3-methoxyphenyl)methanesulfonamide → 6-(cyclohexylamino)-N-{2-methoxy-4-[(methylsulfonyl)amino]phenyl}pyrimidine-4-carboxamide

https://huagongshe.com/reaction/1746712

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(4-amino-3-methoxyphenyl)methanesulfonamideHCID 290500—
Reactant6-(Cyclohexylamino)pyrimidine-4-carboxylic acidHCID 59447075—
SolventDichloromethaneHCID 6344—
Product6-(cyclohexylamino)-N-{2-methoxy-4-[(methylsulfonyl)amino]phenyl}pyrimidine-4-carboxamideHCID 25182764—

Reaction Steps

Following the general method as outlined in Example 1, starting from 6-(cyclohexylamino)pyrimidine-4-carboxylic acid (Intermediate 4) and N-(4-amino-3-methoxyphenyl)methanesulfonamide (Kaironkem), the title compound was obtained as a white solid after trituration in DCM.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09150519B2
Source datasetuspto-grants-2015_10
ORD IDord-e9862e2a7baa49f69fcf132da86631b0
Source noteuspto-grants-2015_10