1H-Indazol-5-amine → 6-(cyclohexylamino)-N-1H-indazol-5-ylpyrimidine-4-carboxamide

HRID 1746713Notes

Reaction equation

HRID 1746713 reaction equation
[CH:1]1([NH:7][C:8]2[N:13]=[CH:12][N:11]=[C:10]([C:14]([OH:16])=O)[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][N:22]=[CH:21]2>C(Cl)Cl>[CH:1]1([NH:7][C:8]2[N:13]=[CH:12][N:11]=[C:10]([C:14]([NH:17][C:18]3[CH:19]=[C:20]4[C:24](=[CH:25][CH:26]=3)[NH:23][N:22]=[CH:21]4)=[O:16])[CH:9]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 880121H-Indazol-5-amineHCID 594470756-(Cyclohexylamino)pyrimidine-4-carboxylic acid2×

Product 1

HCID 251827656-(cyclohexylamino)-N-1H-indazol-5-ylpyrimidine-4-carboxamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following the general method as outlined in Example 1, starting from 6-(cyclohexylamino)pyrimidine-4-carboxylic acid (Intermediate 4) and 5-aminoindazole (Aldrich), the title compound was obtained as a pink solid after trituration in DCM.

Sources & evidence

ORD record
ord-f4e94e93c53340e6893ecfe45d35cd53
Source dataset
uspto-grants-2015_10
Patent number
US09150519B2

Reaction notes

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