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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1746714Generated: November 1, 2026

4-Amino-3-methylbenzene-1-sulfonamide → 6-(cyclohexyl(methyl)amino)-N-(2-methyl-4-sulfamoylphenyl)pyrimidine-4-carboxamide

https://huagongshe.com/reaction/1746714

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Amino-3-methylbenzene-1-sulfonamideHCID 143037—
Reactant6-[Cyclohexyl(methyl)amino]pyrimidine-4-carboxylic acidHCID 59447077—
Product6-(cyclohexyl(methyl)amino)-N-(2-methyl-4-sulfamoylphenyl)pyrimidine-4-carboxamideHCID 25182766—

Reaction Steps

Following the general method as outlined in Example 1, starting from 6-[cyclohexyl(methyl)amino]pyrimidine-4-carboxylic acid (Intermediate 10) and 4-amino-3-methyl-benzenesulfonamide (Biofine), the title compound was obtained as a white solid after purification by preparative HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09150519B2
Source datasetuspto-grants-2015_10
ORD IDord-da70a52751244ef48a57a23a7c4c4083
Source noteuspto-grants-2015_10