4-Amino-N-ethylbenzenesulfonamide → 6-[cyclohexyl(methyl)amino]-N-{4-[(ethylamino)sulfonyl]phenyl}pyrimidine-4-carboxamide

HRID 1746716Notes

Reaction equation

HRID 1746716 reaction equation
[CH:1]1([N:7]([CH3:17])[C:8]2[N:13]=[CH:12][N:11]=[C:10]([C:14]([OH:16])=O)[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([S:25]([NH:28][CH2:29][CH3:30])(=[O:27])=[O:26])=[CH:21][CH:20]=1>CO>[CH:1]1([N:7]([CH3:17])[C:8]2[N:13]=[CH:12][N:11]=[C:10]([C:14]([NH:18][C:19]3[CH:24]=[CH:23][C:22]([S:25]([NH:28][CH2:29][CH3:30])(=[O:27])=[O:26])=[CH:21][CH:20]=3)=[O:16])[CH:9]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 5935724-Amino-N-ethylbenzenesulfonamideHCID 594470776-[Cyclohexyl(methyl)amino]pyrimidine-4-carboxylic acid2×

Product 1

HCID 594468796-[cyclohexyl(methyl)amino]-N-{4-[(ethylamino)sulfonyl]phenyl}pyrimidine-4-carboxamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Following the general method as outlined in Example 1, starting from 6-[cyclohexyl(methyl)amino]pyrimidine-4-carboxylic acid (Intermediate 10) and 4-amino-N-ethyl-benzenesulfonamide (Oakwood), the title compound was obtained as a white solid after trituration in methanol.

Sources & evidence

ORD record
ord-b48b0e5336dc4e28b042d10dfdfcf4fa
Source dataset
uspto-grants-2015_10
Patent number
US09150519B2

Reaction notes

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