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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1746718Generated: October 31, 2026

1H-Indazol-5-amine → 6-[cyclohexyl(methyl)amino]-N-1H-indazol-5-ylpyrimidine-4-carboxamide

https://huagongshe.com/reaction/1746718

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1H-Indazol-5-amineHCID 88012—
Reactant6-[Cyclohexyl(methyl)amino]pyrimidine-4-carboxylic acidHCID 59447077—
Product6-[cyclohexyl(methyl)amino]-N-1H-indazol-5-ylpyrimidine-4-carboxamideHCID 25182770—

Reaction Steps

Following the general method as outlined in Example 1, starting from 6-[cyclohexyl(methyl)amino]pyrimidine-4-carboxylic acid (Intermediate 10) and 5-aminoindazole (Aldrich), the title compound was obtained as a white solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09150519B2
Source datasetuspto-grants-2015_10
ORD IDord-b6b1baf7ca1c4d219c7e5812f583d958
Source noteuspto-grants-2015_10