4-amino-N-(2-hydroxyethyl)benzenesulfonamide → HCID 25182772, compound

Participants

Reaction Steps

Following the general method as outlined in Example 1, starting from 6-[cyclohexyl(methyl)amino]pyrimidine-4-carboxylic acid (Intermediate 10) and 4-amino-N-(2-hydroxyethyl)benzenesulfonamide (prepared according to the method described by R. N. Misra et al. in Bioorg. Med. Chem. Lett. 2004, 14, 2973-2977), the title compound was obtained as a white solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.

Provenance & Evidence