6-methyl-1H-indazol-5-amine → 6-(cyclohexyl(methyl)amino)-N-(6-methyl-1H-indazol-5-yl)pyrimidine-4-carboxamide

HRID 1746722Notes

Reaction equation

HRID 1746722 reaction equation
[CH:1]1([N:7]([CH3:17])[C:8]2[N:13]=[CH:12][N:11]=[C:10]([C:14]([OH:16])=O)[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:18][C:19]1[CH:20]=[C:21]2[C:25](=[CH:26][C:27]=1[CH3:28])[NH:24][N:23]=[CH:22]2>C(Cl)Cl>[CH:1]1([N:7]([CH3:17])[C:8]2[N:13]=[CH:12][N:11]=[C:10]([C:14]([NH:18][C:19]3[CH:20]=[C:21]4[C:25](=[CH:26][C:27]=3[CH3:28])[NH:24][N:23]=[CH:22]4)=[O:16])[CH:9]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 14825826-methyl-1H-indazol-5-amineHCID 594470776-[Cyclohexyl(methyl)amino]pyrimidine-4-carboxylic acid2×

Product 1

HCID 251827746-(cyclohexyl(methyl)amino)-N-(6-methyl-1H-indazol-5-yl)pyrimidine-4-carboxamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following the general method as outlined in Example 1, starting from 6-[cyclohexyl(methyl)amino]pyrimidine-4-carboxylic acid (Intermediate 10) and 5-amino-6-methylindazole (Bionet), the title compound was obtained as a beige solid after trituration in DCM.

Sources & evidence

ORD record
ord-7b0a25b5705749ff9717d1024e6b89e5
Source dataset
uspto-grants-2015_10
Patent number
US09150519B2

Reaction notes

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