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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1746723Generated: October 31, 2026

4-amino-N-(2,3-dihydroxypropyl)benzenesulfonamide → 6-[cyclohexyl(methyl)amino]-N-(4-{[(2,3-dihydroxypropyl)amino]sulfonyl}phenyl)pyrimidine-4-carboxamide

https://huagongshe.com/reaction/1746723

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-amino-N-(2,3-dihydroxypropyl)benzenesulfonamideHCID 59446956—
Reactant6-[Cyclohexyl(methyl)amino]pyrimidine-4-carboxylic acidHCID 59447077—
SolventDichloromethaneHCID 6344—
Product6-[cyclohexyl(methyl)amino]-N-(4-{[(2,3-dihydroxypropyl)amino]sulfonyl}phenyl)pyrimidine-4-carboxamideHCID 25182775—

Reaction Steps

Following the general method as outlined in Example 1, starting from 6-[cyclohexyl(methyl)amino]pyrimidine-4-carboxylic acid (Intermediate 10) and 4-amino-N-(2,3-dihydroxypropyl)benzenesulfonamide (Intermediate 14), the title compound was obtained as a white solid after trituration in DCM.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09150519B2
Source datasetuspto-grants-2015_10
ORD IDord-cecf16a0d7494936a46bb2bbce1306ce
Source noteuspto-grants-2015_10