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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1746727Generated: November 1, 2026

4-Aminopyridine → 6-[cyclohexyl(cyclopropylmethyl)amino]-N-pyridin-4-ylpyrimidine-4-carboxamide

https://huagongshe.com/reaction/1746727

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-AminopyridineHCID 1727—
Reactant6-[Cyclohexyl(cyclopropylmethyl)amino]pyrimidine-4-carboxylic acidHCID 59446841—
Product6-[cyclohexyl(cyclopropylmethyl)amino]-N-pyridin-4-ylpyrimidine-4-carboxamideHCID 25182903—

Reaction Steps

Following the general method as outlined in Example 1, starting from 6-[cyclohexyhcyclopropylmethyl)amino]pyrimidine-4-carboxylic acid (Intermediate 13) and 4-aminopyridine (Tyger), the title compound was obtained as a white solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09150519B2
Source datasetuspto-grants-2015_10
ORD IDord-d1b7871a71584226b8dba886cd6b7430
Source noteuspto-grants-2015_10