4-Aminobenzamide → HCID 25182778, compound

HRID 1746728Notes

Reaction equation

HRID 1746728 reaction equation
[CH:1]1([N:7]([CH2:17][CH:18]2[CH2:20][CH2:19]2)[C:8]2[N:13]=[CH:12][N:11]=[C:10]([C:14]([OH:16])=O)[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:21][C:22]1[CH:30]=[CH:29][C:25]([C:26]([NH2:28])=[O:27])=[CH:24][CH:23]=1>C(Cl)Cl>[NH2:28][C:26]([C:25]1[CH:29]=[CH:30][C:22]([NH:21][C:14]([C:10]2[CH:9]=[C:8]([N:7]([CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)[CH2:17][CH:18]3[CH2:20][CH2:19]3)[N:13]=[CH:12][N:11]=2)=[O:16])=[CH:23][CH:24]=1)=[O:27]

Participants

4

Reactant 2

HCID 760794-AminobenzamideHCID 594468416-[Cyclohexyl(cyclopropylmethyl)amino]pyrimidine-4-carboxylic acid2×

Product 1

HCID 25182778HCID 25182778, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following the general method as outlined in Example 1, starting from 6-[cyclohexyhcyclopropylmethyl)amino]pyrimidine-4-carboxylic acid (Intermediate 13) and 4-aminobenzamide (Aldrich), the title compound was obtained as a brown solid in 85% yield after trituration in DCM.

Sources & evidence

ORD record
ord-22468a12552c469999b67fb7eef6f369
Source dataset
uspto-grants-2015_10
Patent number
US09150519B2

Reaction notes

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