6-[Cyclohexyl(cyclopropylmethyl)amino]pyrimidine-4-carboxylic acid → 6-[cyclohexyl(cyclopropylmethyl)amino]-N-(4-{[(2,3-dihydroxypropyl)amino]sulfonyl}phenyl)pyrimidine-4-carboxamide

Participants

Reaction Steps

Following the general method as outlined in Example 1, starting from 6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidine-4-carboxylic acid (Intermediate 13) and 4-amino-N-(2,3-dihydroxypropyl)benzenesulfonamide (Intermediate 15), the title compound was obtained as a brown solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.

Provenance & Evidence