HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(2-methoxyethyl)cyclohexanamine → N-[4-(aminosulfonyl)-2-methylphenyl]-6-[cyclohexyl(2-methoxyethyl)amino]pyrimidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(2-methoxyethyl)cyclohexanamine | HCID 12687399 | — |
| Reactant | 6-Chloro-pyrimidine-4-carboxylic acid (2-methyl-4-sulfamoyl-phenyl)amide | HCID 59447056 | — |
| Product | N-[4-(aminosulfonyl)-2-methylphenyl]-6-[cyclohexyl(2-methoxyethyl)amino]pyrimidine-4-carboxamide | HCID 25182783 | 82% |
Reaction Steps
Following the general method as outlined in Example 20, starting from 6-chloro-pyrimidine-4-carboxylic acid (2-methyl-4-sulfamoyl-phenyl)-amide (Intermediate 17) and cyclohexyl-(2-methoxy-ethyl)-amine (Intermediate 26), the title compound was obtained as a white solid in 82% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150519B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-c52da0bdf316450fa099b96a0eacc2d4 |
| Source note | uspto-grants-2015_10 |