HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bis(2-Methoxyethyl)amine → N-[4-(aminosulfonyl)-2-methylphenyl]-6-[bis(2-methoxyethyl)amino]pyrimidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bis(2-Methoxyethyl)amine | HCID 2383 | — |
| Reactant | 6-Chloro-pyrimidine-4-carboxylic acid (2-methyl-4-sulfamoyl-phenyl)amide | HCID 59447056 | — |
| Product | N-[4-(aminosulfonyl)-2-methylphenyl]-6-[bis(2-methoxyethyl)amino]pyrimidine-4-carboxamide | HCID 25182907 | 84% |
Reaction Steps
Following the general method as outlined in Example 20, starting from 6-chloro-pyrimidine-4-carboxylic acid (2-methyl-4-sulfamoyl-phenyl)-amide (Intermediate 17) and bis(2-methoxyethyl)amine (Aldrich), the title compound was obtained as a white solid in 84% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150519B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-2a5fda83b9644b3cb3364e94430a3115 |
| Source note | uspto-grants-2015_10 |