HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(2-Methoxyethyl)isopropylamine → N-1H-indazol-5-yl-6-[isopropyl(2-methoxyethyl)amino]pyrimidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(2-Methoxyethyl)isopropylamine | HCID 551575 | — |
| Reactant | 6-chloro-N-1H-indazol-5-ylpyrimidine-4-carboxamide | HCID 59446880 | — |
| Product | N-1H-indazol-5-yl-6-[isopropyl(2-methoxyethyl)amino]pyrimidine-4-carboxamide | HCID 25182931 | — |
Reaction Steps
Following the general method as outlined in Example 20, starting from 6-chloro-pyrimidine-4-carboxylic acid (1H-indazol-5-yl)-amide (Intermediate 16) and N-(2-methoxyethyl)isopropylamine (ABCR), the title compound was obtained as a yellow solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150519B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-6bec25e0d9da403c98bd50b026325df9 |
| Source note | uspto-grants-2015_10 |