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HRID 1746761作成日：2026年10月25日

Cyclopropanemethanamine, N-propyl- → N-[4-(aminomethyl)phenyl]-6-[(cyclopropylmethyl)(propyl)amino]pyrimidine-4-carboxamide

https://huagongshe.com/reaction/1746761

反応式

関与物質

役割名称HCID仕込み量
反応物Cyclopropanemethanamine, N-propyl-HCID 117787—
反応物Tert-butyl (4-{[(6-chloropyrimidin-4-yl)carbonyl]amino}benzyl)carbamateHCID 59447092—
生成物N-[4-(aminomethyl)phenyl]-6-[(cyclopropylmethyl)(propyl)amino]pyrimidine-4-carboxamideHCID 25182932—

反応手順

Following the general method as outlined in Example 72 (Steps 1 and 2), starting from tert-butyl (4-{[(6-chloropyrimidin-4-yl)carbonyl]amino}benzyl)carbamate (Intermediate 22) and N-propylcyclopropanemethylamine (Aldrich), the title compound was obtained as a beige solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09150519B2
出典データセットuspto-grants-2015_10
ORD IDord-c04b98ba0f144649bda057b57a0a260b
出典メモuspto-grants-2015_10