(Cyclopropylmethyl)(2-methoxyethyl)amine → N-[4-(aminomethyl)phenyl]-6-[(cyclopropylmethyl)(2-methoxyethyl)amino]pyrimidine-4-carboxamide hydrochloride

Participants

Reaction Steps

Following the general method as outlined in Example 72 (Steps 1 and 2), starting from tert-butyl (4-{[(6-chloropyrimidin-4-yl)carbonyl]amino}benzyl)carbamate (Intermediate 22) and N-(cyclopropylmethyl)-2-methoxyethanamine, the title compound was obtained as a pale yellow solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.

Provenance & Evidence