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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1746780Generated: October 30, 2026

4-(Methylsulfonyl)aniline → 6-(cyclohexyl(cyclopropylmethyl)amino)-N-(4-(methylsulfonyl)phenyl)pyrimidine-4-carboxamide

https://huagongshe.com/reaction/1746780

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Methylsulfonyl)anilineHCID 79617—
Reactant6-[Cyclohexyl(cyclopropylmethyl)amino]pyrimidine-4-carboxylic acidHCID 59446841—
Product6-(cyclohexyl(cyclopropylmethyl)amino)-N-(4-(methylsulfonyl)phenyl)pyrimidine-4-carboxamideHCID 46880925—

Reaction Steps

Following the general method as outlined in Example 1, starting from 6-(cyclohexyl-cyclopropylmethyl-amino)-pyrimidine-4-carboxylic acid (Intermediate 13) and 4-(methylsulfonyl)aniline (Enamine), the title compound was obtained as a white solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09150519B2
Source datasetuspto-grants-2015_10
ORD IDord-f5bef274c84040b1a95c5f5c078eb5a8
Source noteuspto-grants-2015_10