5-Aminobenzimidazole → HCID 178457014, compound

HRID 1746789Notes

Reaction equation

HRID 1746789 reaction equation
[CH:1]1([CH2:4][N:5]([CH2:15][CH2:16][CH3:17])[C:6]2[N:11]=[CH:10][N:9]=[C:8]([C:12]([OH:14])=O)[CH:7]=2)[CH2:3][CH2:2]1.[NH2:18][C:19]1[CH:27]=[CH:26][C:22]2[N:23]=[CH:24][NH:25][C:21]=2[CH:20]=1>>[NH:23]1[C:22]2[CH:26]=[CH:27][C:19]([NH:18][C:12]([C:8]3[CH:7]=[C:6]([N:5]([CH2:4][CH:1]4[CH2:2][CH2:3]4)[CH2:15][CH2:16][CH3:17])[N:11]=[CH:10][N:9]=3)=[O:14])=[CH:20][C:21]=2[N:25]=[CH:24]1

Participants

3

Reactant 2

HCID 136235-AminobenzimidazoleHCID 594470006-[(Cyclopropylmethyl)(propyl)amino]pyrimidine-4-carboxylic acid2×

Product 1

HCID 178457014HCID 178457014, compound

Procedure

Following the general method as outlined in Example 1, starting from 6-(cyclopropylmethyl-propyl-amino)-pyrimidine-4-carboxylic acid (Intermediate 21) and 5-aminobenzimidazole (ABCR), the title compound was obtained as a white solid after purification by preparative HPLC.

Sources & evidence

ORD record
ord-e464eddc6d3148a1915ac5176cf496f2
Source dataset
uspto-grants-2015_10
Patent number
US09150519B2

Reaction notes

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