Tetrahydrofuran → HCID 86702588, compound

Participants

Reaction Steps

To an anhydrous tetrahydrofuran (2.7 mL) solution of dimethyl (2-oxo-3-phenoxypropyl)phosphonate (194 mg) was added sodium hydride (24.8 mg) in an ice bath, and the mixture was stirred at room temperature for 1.5 hours. Thereto was added dropwise an anhydrous tetrahydrofuran (2 mL) solution of the compound 11 (200 mg), and the mixture was reacted at room temperature for 4.5 hours. Acetic acid was added in a small amount, and the reaction liquid was then diluted with ethyl acetate. This solution was washed with water and a saturated saline, dried with anhydrous magnesium sulfate, and then concentrated to obtain a titled compound (250 mg) having the following physical property values.

Provenance & Evidence