HCID 89644375, compound → HCID 89644341, compound

HRID 1746843Notes

Reaction equation

HRID 1746843 reaction equation
[CH3:1][O:2][C:3](=[O:55])/[C:4](/[N:41]1[CH2:45][CH2:44][C@H:43]([NH:46][C:47]([O:49][C:50]([CH3:53])([CH3:52])[CH3:51])=[O:48])[C:42]1=[O:54])=[CH:5]\[C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[O:16][C:17]([F:20])([F:19])[F:18])[C:12]([NH:21][C:22]([C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[N:11][CH:10]=[CH:9]2>CO>[CH3:1][O:2][C:3](=[O:55])[C@H:4]([N:41]1[CH2:45][CH2:44][C@H:43]([NH:46][C:47]([O:49][C:50]([CH3:51])([CH3:52])[CH3:53])=[O:48])[C:42]1=[O:54])[CH2:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[O:16][C:17]([F:20])([F:19])[F:18])[C:12]([NH:21][C:22]([C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)([C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)=[N:11][CH:10]=[CH:9]2

Participants

3

Reactant 1

HCID 89644375HCID 89644375, compound

Product 1

HCID 89644341HCID 89644341, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.35 g (1.8 mmol) of (E)-2-((S)-3-tert-Butoxycarbonylamino-2-oxo-pyrrolidin-1-yl)-3-[7-trifluoromethoxy-1-(trityl-amino)-isoquinolin-6-yl]acrylic acid methyl ester are dissolved in 50 ml abs. Methanol.

Sources & evidence

ORD record
ord-5696d4ca68f14a19812abee30226f476
Source dataset
uspto-grants-2015_10
Patent number
US09150544B2

Reaction notes

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