Sodium borohydride → HCID 89852607, compound

Participants

Reaction Conditions

Reaction Steps

To ethyl 2-(3-formyl-1H-pyrazol-1-yl)nicotinate (6 g, 9.79 mmol) in ethanol (100 mL) at 10° C. NaBH4 (0.741 g, 19.57 mmol) was added and stirred at 25° C. for 1 hr. For work up the mixture was poured into 200 mL of ice water, extracted twice with ethyl acetate, the combined organic layers subsequently washed with water and brine, dried (MgSO4), filtered and concentrated to give 7.2 g of a yellow oil. Purification by chromatography over silica gel (eluent CH2Cl2+0-10% methanol) gave 2.36 g of the corresponding title compound as clear oil; ESI-MS [M+H]+: 248.1.

Provenance & Evidence