Dichloromethane → HCID 89851983, compound

Participants

Reaction Steps

To a solution of ethyl 2-(3-(hydroxymethyl)-1H-pyrazol-1-yl)nicotinate (3.76 g, 13.69 mmol) in dichloromethane (100 mL) thionyl chloride (1.1 mL, 15.07 mmol) was added dropwise under stirring. After the reaction was completed, the mixture was concentrated and purified by chromatography over silica gel (eluent CH2Cl2+0-5% methanol) to give 3.7 g of the title compound as clear oil; ESI-MS [M+H]+: 266.1. 1H-NMR (400 MHz, DMSO), δ[ppm]: 8.64 (dd, 1H), 8.49 (d, 1H), 8.13 (dd, 1H), 7.53 (dd, 1H), 6.65 (d, 2H), 4.23 (q, 2H), 1.17 (t, 3H).

Provenance & Evidence