Potassium Carbonate → HCID 89852354, compound

Participants

Reaction Steps

The mixture of ethyl 2-(3-(chloromethyl)-1H-pyrazol-1-yl)nicotinate (500 mg, 1.882 mmol), 4,4-difluoropiperidine (328 mg, 2.7 mmol), and K2CO3 were stirred at room temperature in acetonitrile (25 mL) until completion of the reaction. The mixture was concentrated, pardoned between water and dichlormethane (60 mL), the organic layer separated, washed twice with water, dried (MgSO4), filtered and dried to give a brown oil, which then was purified by chromatography over silica gel (CH2Cl2+methanol) to yield 620 mg of the title compound as clear oil. ESI-MS [M+H]+: 351.15.

Provenance & Evidence