HCID 89852374, compound → HCID 71768639, compound

Participants

Reaction Steps

Oxidation of N-(4-amino-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-2-(3-(isoindolin-2-ylmethyl)-1H-pyrazol-1-yl)nicotinamide (1.05 g, 2.115 mmol) as described in example 1.4, treatment of the crude product with ethyl acetate gave the title compound as white amorphous solid; 421 mg, ESI-MS [M+H]+: 495.2. 1H-NMR (400 MHz, DMSO), 6 [ppm]: 8.97 (m, 1H), 8.55 (m, 1H), 8.32 (m, 1H), 8.03 (m, 1H), 7.79 (m, 1H), 7.72 (m, 1H), 7.42 (m, 1H), 7.29-7.15 (m, 9H), 6.47 (m, 1H), 5.42 (m, 1H), 3.80 (s, 4H), 3.68 (m, 2H), 3.15 and 2.87 (each dd, 1H).

Provenance & Evidence