HCID 89855437, compound → HCID 71768673, compound

Participants

Reaction Steps

Oxidation of N-(4-amino-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-2-(3-((4-tert-butylpiperidin-1-yl)methyl)-1H-pyrazol-1-yl)nicotinamide (200 mg, 0.386 mmol) as described in example 1.4, recrystallization of the crude product from CH2Cl2/MTB gave the title compound as white amorphous solid; 34 mg, ESI-MS [M+H]+: 517.2. 1H-NMR (400 MHz, DMSO), δ[ppm]: 8.94 (m, 1H), 8.52 (m, 1H), 8.30 (m, 1H), 8.05 (m, 1H), 7.82 (m, 1H), 7.74 (m, 1H), 7.43 (m, 5H), 6.37 (m, 1H), 5.36 (m, 1H), 3.27 (m, overlapping with water), 2.88 (m, 3H), 1.75 (m, 2H), 1.54 (m, 2 h), 1.15 (m, 2H), 0.82 (m, 11H).

Provenance & Evidence