Ethyl Acetate → HCID 71768707, compound

Participants

Reaction Steps

Oxidation of N-(4-amino-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-2-(3-((phenylamino)methyl)-1H-pyrazol-1-yl)nicotinamide (120 mg, 0.255 mmol) as described in example 1.4, subsequent crystallization of the crude product from 2-propanole and then from ethylacetate afforded the title compound as white amorphous solid; 80 mg, ESI-MS [M+H]+: 523.3. 1H-NMR (400 MHz, DMSO), δ[ppm]: 8.93 (m, 1H), 8.50 (m, 1H), 8.32 (m, 1H), 8.06 (m, 1H), 7.82 (m, 1H), 7.71 (m, 1H), 7.42-7.25 (m, 10H), 6.42 (m, 1H), 5.38 (m, 1H), 3.49 (m, 2H), 3.25 (m, 1H), 3.17 (dd, 1H), 2.88 (m, 2H), 2.63 (m, 2H), 2.39 (m, 1H), 2.21 (m, 1H), 1.72 (m, 1H).

Provenance & Evidence