HCID 117926008, compound → HCID 71768773, compound

Participants

Reaction Steps

Oxidation of N-(1-amino-2-hydroxy-1-oxoheptan-3-yl)-2-(3-(piperidin-1-ylmethyl)-1H-pyrazol-1-yl)nicotinamide (180 mg, 0.378 mmol) as described in example 1.4 and treatment of the crude product with a mixture of ethyl acetate and MTB 1:1, filtering off the remaining solid and drying gave the title compound as white amorphous solid; 63 mg, ESI-MS [M+H]+: 427.2. 1H-NMR (400 MHz, DMSO), δ[ppm]: 8.67 (d, 1H), 8.51 (m, 1H), 8.33 (m, 1H), 7.99 (m, 1H), 7.82 (m, 1H), 7.75 (m, 1H), 7.44 (m, 1H), 6.40 (m, 1H), 5.07 (m, 1H), 3.40 (s, 2H), 2.33 (m, 4H), 1.76 (m, 1H), 1.48 (m, 5H), 1.36 (m, 6H), 0.87 (m, 3H).

Provenance & Evidence