HCID 117926009, compound → HCID 71768809, compound

Participants

Reaction Steps

Oxidation of tert-butyl 2-(3-(4-amino-3-hydroxy-4-oxo-1-phenylbutan-2-ylcarbamoyl)pyridin-2-yl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate (88 mg, 0.174 mmol) as described in example 1.4 and purification by chromatography over Chromabond RP-C18 (eluent: water/acetonitrile) gave 55 mg of an amorphous solid; ESI-MS [M+H]+: 505.2. 1H-NMR (400 MHz, DMSO), δ[ppm]: 8.83 (m, 1H), 8.52 (m, 1H), 8.15 (m, 1H), 8.06 (m, 1H), 7.84 (m, 1H), 7.72 (m, 1H), 7.44 (m, 1H), 7.23 (m, 4H), 7.17 (m, 1H), 5.26 (m, 1H), 4.35 (m, 2H), 4.18 (m, 1H), 4.0 (m, 1H), 3.09 (m, 1H), 2.73 (m, 1H), 1.49 (s, 9H).

Provenance & Evidence