HCID 59478358, compound → HCID 59478475, compound

HRID 1747043Notes

Reaction equation

HRID 1747043 reaction equation
C(OC(=O)[NH:10][C@H:11]([CH2:14][NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH2:12][OH:13])C1C=CC=CC=1>[Pd].C(O)C>[NH2:10][C@@H:11]([CH2:12][OH:13])[CH2:14][NH:15][S:16]([CH3:19])(=[O:18])=[O:17]

Participants

4

Reactant 1

HCID 59478358HCID 59478358, compound

Product 1

HCID 59478475HCID 59478475, compoundYield 99.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a mixed liquid of 3.10 g of benzyl[(1R)-2-hydroxy-1-{[(methylsulfonyl)amino]methyl}ethyl]carbamate and 50 ml of ethanol was added 500 mg of 5% palladium/carbon, followed by stirring at room temperature for 2 hours under a hydrogen atmosphere. The palladium/carbon was separated by filtration and the solvent was then evaporated to obtain 1.72 g of N-[(2R)-2-amino-3-hydroxypropyl]methanesulfonamide as a colorless oily substance.

Workup

  1. customThe palladium/carbon was separated by filtration
  2. customthe solvent was then evaporated

Sources & evidence

ORD record
ord-4416131e4c57447a99c298173bf0bf33
Source dataset
uspto-grants-2015_10
Patent number
US09150541B2

Reaction notes

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