HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron → (3S)-4,4-Dimethoxytetrahydro-2H-pyran-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron | HCID 5462311 | — |
| Reactant | 4,4-Dimethoxyoxan-3-one | HCID 11848643 | — |
| Product | (3S)-4,4-Dimethoxytetrahydro-2H-pyran-3-ol | HCID 66979040 | — |
Reaction Steps
reacting 4,4-dimethoxydihydro-2H-pyran-3(4H)-one with a boron reducing agent and R-(+)-2-methyl-CBS-oxazaborolidine, over a period of at least six hours to provide the (S)-4,4-dimethoxytetrahydro-2H-pyran-3-ol in at least 60% enantiomeric excess, wherein the reaction is run at a temperature range from 20° C. to 60° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150532B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-e1d6037923174a4383acbdbbc3eae6d4 |
| Source note | uspto-grants-2015_10 |