Sodium Carbonate → HCID 86708149, compound

Participants

Reaction Steps

A solution of the product of Step B (50 mg, 0.09 mmol, 1 eq), phenylboronic acid (22 mg, 0.18 mmol, 2 eq), (Ph3P)4Pd (10 mg, 0.009 mmol, 0.1 eq) and 2 M Na2CO3 (0.1 mL) in dimethoxyethane (1 mL) under N2 was warmed to 80 C in a screw-top vial overnight. The solution was cooled to rt, and concentrated. Purification by column chromatography (4 g) eluting with 50 to 100% ethyl acetate/heptane afforded the title compound of Step C. Calculated for C28H30F3N3O2: 498.2 (M+1). found: 498.3.

Provenance & Evidence