反应详情

A solution of the product of Step D (5.39 g, 11.1 mmol, 1 eq) and hydrazine (7.1 mL, 222 mmol, 20 eq) in ethanol (60 mL) was stirred at rt 18 hours. The white solid was filtered, washed with methanol and DCM, and the filtrates concentrated. Saturated NaHCO3 was added, the aqueous extracted with DCM, the organics combined, dried over MgSO4 and concentrated to afford the product of Step E. Calculated for C17H19F3N2O3: 357.1 (M+1). found: 357.3.

1. filtrationThe white solid was filtered
2. washwashed with methanol and DCM
3. concentrationthe filtrates concentrated
4. additionSaturated NaHCO3 was added
5. extractionthe aqueous extracted with DCM
6. dry with materialdried over MgSO4
7. concentrationconcentrated